Melasma is a common hypermelanotic disorder affecting the facial area which has a considerable psychological impact on the patient. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents, such as rucinol and sophora-alpha. Aims. We aim to compare the combined treatment of skin needling and depigmenting serum with that using depigmenting serum alone in the treatment of melasma, in order to evaluate the use of microneedles as a means to enhance the drug's transdermal penetration. Methods. Twenty patients were treated with combined skin needling and depigmenting serum on one side of the face and with depigmenting serum alone on the other side. The outcome was evaluated periodically for up to two months using the Melasma Area Severity Index score and the Spectrocolorimeter X-Rite 968. Results. The side with combined treatment (skin needling + depigmenting serum) presented a statistically significant reduction in MASI score and luminosity index (L) levels compared to the side treated with depigmenting serum alone, and clinical symptoms were significantly improved. Conclusions. Our study suggests the potential use of combining skin needling with rucinol and sophora-alpha compounds to achieve better results in melasma treatment compared to rucinol and sophora-alpha alone.
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机译：黄褐斑是影响面部区域的常见高黑素病，对患者的心理影响很大。处理黄褐斑是一项艰巨的挑战，需要长期使用多种局部用药（例如芸香酚和槐糖α）进行长期治疗。目的我们的目的是比较皮肤针刺和脱色血清与单独使用脱色血清治疗黄褐斑的组合治疗，以评估使用微针作为增强药物透皮渗透性的方法。方法。 20例患者的面部一侧分别接受了皮肤针刺和色素沉着的联合治疗，而另一侧仅接受了色素沉着的联合治疗。使用Melasma Area Severity Index评分和分光色度计X-Rite 968定期评估结果，长达两个月。结果。与仅使用脱色血清治疗的一侧相比，联合治疗（皮肤针刺+脱色血清）的一侧在统计学上显着降低了MASI评分和光度指数（L）水平，并且临床症状得到明显改善。结论。我们的研究表明，将皮肤针刺与芸香酚和槐糖苷-α化合物相结合的潜在用途与单独使用芸香酚和槐糖酚-α相比，在黄褐斑治疗中可获得更好的效果。
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