首页> 美国卫生研究院文献>Oncotarget >Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis
【2h】

Identifying characteristic miRNAs-genes and risk pathways of multiple sclerosis based on bioinformatics analysis

机译:基于生物信息学分析鉴定多发性硬化症的特征性miRNAs基因和危险途径

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。

摘要

Multiple sclerosis is a chronic autoimmune disorder of the central nervous system. In MS, the genetic susceptibility is high and currently there is no effective treatment. MicroRNA, a small non-coding RNA, plays a vital role in immune responses. Aberrant or dysfunctional miRNAs may cause several diseases, including MS, thus miRNAs and miRNA related genes may be therapeutic weapons against MS. Here, we identified 21 miRNAs in peripheral blood mono-nuclear cells from over 600 persons, including healthy controls. By using informatics databases, 1637 susceptibility genes were evaluated and Cytoscape was used to integrate and visualize the relation between the miRNA identified and susceptibility genes. By using the cluster Profile package, a total of 10 risk pathways were discovered. Top pathways included: hsa05200 (pathway in cancer), hsa04010 (MAPK signaling pathway), and hsa04060 (cytokine-cytokine receptor interaction). By using the STRING database, a protein-protein interaction network was conducted to identify highly susceptibility genes. Moreover, the dataset was used to indicate the gene expression profiles and to correct prediction results, thereby identifying the most pivotal genes. The MiRSystem database provided information on both pivotal miRNAs and genes. In conclusion, miR-199a and miR-142-3p may be crucial for MS by targeting pivotal susceptibility genes, in particular KRAS and IL7R.
机译:多发性硬化症是中枢神经系统的慢性自身免疫性疾病。在MS中,遗传易感性高,目前尚无有效的治疗方法。 MicroRNA是一种小的非编码RNA,在免疫反应中起着至关重要的作用。异常或功能异常的miRNA可能引起多种疾病,包括MS,因此miRNA和miRNA相关基因可能是抵抗MS的治疗武器。在这里,我们从包括健康对照组在内的600多人中,在外周血单核细胞中鉴定出21种miRNA。通过使用信息学数据库,评估了1637个敏感性基因,并使用Cytoscape整合并可视化了所鉴定的miRNA与敏感性基因之间的关系。通过使用集群概要文件包,总共发现了10条风险路径。热门途径包括:hsa05200(癌症途径),hsa04010(MAPK信号传导途径)和hsa04060(细胞因子-细胞因子受体相互作用)。通过使用STRING数据库,进行了蛋白质-蛋白质相互作用网络以鉴定高度易感基因。此外,该数据集用于指示基因表达谱并纠正预测结果,从而鉴定出最关键的基因。 MiRSystem数据库提供了有关关键miRNA和基因的信息。总之,通过靶向关键敏感性基因,特别是KRAS和IL7R,miR-199a和miR-142-3p对于MS可能至关重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号