Expression of organic anion-transporting polypeptides 1B3 1B1 and 1A2 in human pancreatic cancer reveals a new class of potential therapeutic targets

摘要

Background:Organic anion-transporting polypeptides (OATPs) are influx transporters that mediate intracellular uptake of selective endogenous and xenobiotic compounds. Identification of new molecular targets and discovery of novel targeted therapies is top priority for pancreatic cancer, which lacks any effective therapy.