(3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one attenuates hyperglycemia increased hepatic glycogen content and hepatic damage induced by malathion acute exposure in rats

摘要

BackgroundOrganophosphorus pesticides (OP’s) are heavily constituted in agriculture, gardens, home and veterinary and although it is useful, there are concerns about the environment, safety and health of human and animals. In this study, we investigated the effects of a new oxime, (3Z)-5-Chloro-3-(Hydroxyimino)indolin-2-one (OXIME) against the alterations induced by malathion, an OP insecticide, acute exposure on markers of hepatic damage, glucose homeostasis, oxidative stress in rats cholinesterase (ChE) activity in rats.