Density Differences Between Hybrid and Nonhybrid Particles in Two Adenovirus-Simian Virus 40 Hybrid Populations

摘要

The adenovirus 7-simian virus 40 hybrid virus population E46⁺ was subjected to fixed-angle equilibrium density gradient centrifugation in CsCl. A difference in buoyant density between the hybrid virion and its nonhybrid adenovirus 7 counterpart was noted, the hybrid virion possessing the lower buoyant density. This difference in buoyant density appeared to be accentuated in a population of adenovirus 2^+t7, a derivative of E46⁺ in which the adenovirus 7-simian virus 40 genome had been transferred to an adenovirus 2 capsid.