Alienating nucleic acids by distant mono- oligo- and polymeric analogs

摘要

Bis-basic 2.7-diamino-9-fluorenones and copolymers of N-vi-nylnucleobases with simple comonomers were prepared for in vitro and in vivo interaction studies in nucleoproteinic systems. Investigations of polynucleotide-effector interactions provide mechanistic support for the observed antiviral in vitro and in vivo efficacies.