Synthesis of 2-S-dioxo isosters of purine and pyrimidine nucleosides

摘要

Preparation of glycosyl derivatives of 3, 5-diamino-4H-, 3,4,5 -triamino-, 3-amino-4-cyano-6H-1, 2, 6-thiadiazine 1,1-dioxide and 4-ethoxy-carbonyl- and 5-methyl-2H, 6H-1, 2, 6-thiadiazin-3-one 1, 1-dioxide is described. Glycosylation reactions of 7-amino-1H, 4H-imidazo[2,3-c]- and 7-amino-4H - furazano[3,4-c] [1, 2, 6]-thiadiazine 5,5-dioxide are also reported. Different synthetic pathways have been used and, in some cases, alkyl derivatives were prepared to be used as model substances in the elucidation of structures.