首页> 美国卫生研究院文献>Neuroscience Bulletin >Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury

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Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury

机译：离体非病毒载体介导的neurotrophin-3基因转移到嗅鞘神经胶质：对脊髓损伤大鼠植入后轴突再生和功能恢复的影响。

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摘要

ObjectiveCombine olfactory ensheathing glia (OEG) implantation with ex vivo non-viral vector-based neurotrophin-3 (NT-3) gene therapy in attempting to enhance regeneration after thoracic spinal cord injury (SCI).

机译：目的结合体外非基于病毒载体的Neurotrophin-3（NT-3）基因疗法联合嗅鞘神经胶质（OEG）植入，以尝试增强胸脊髓损伤（SCI）后的再生。

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期刊名称 Neuroscience Bulletin
作者
Jun Wu; Tian-Sheng Sun; Ji-Xin Ren; Xian-Zhang Wang;
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作者单位

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年(卷),期 2008(24),2
年度 2008
页码 57
总页数 9
原文格式 PDF
正文语种
中图分类神经科学;
关键词
functional recovery gene therapy neurotrophin-3 olfactory ensheathing glia regeneration spinal cord injury non-viral vectors;

机译：功能恢复;基因治疗;Neurotrophin-3;嗅鞘神经胶质细胞;再生;脊髓损伤;非病毒载体;
入库时间 2022-08-17 12:26:20

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专利

1. Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord. [J] . Ruitenberg MJ, Plant GW, Hamers FP, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2003,第18期

机译：体外腺病毒载体介导的神经营养蛋白基因转移到嗅鞘神经胶质细胞：损伤鼠脊髓植入后对脊髓脊髓束再生，病变大小和功能恢复的影响。
2. Xenografts of expanded primate olfactory ensheathing glia support transient behavioral recovery that is independent of serotonergic or corticospinal axonal regeneration in nude rats following spinal cord transection. [J] . Guest JD, Herrera L, Margitich I, Experimental Neurology . 2008,第2期

机译：扩大的灵长类动物嗅觉神经胶质细胞的异种移植支持短暂行为恢复，该行为独立于脊髓横断后裸鼠的血清素能或皮质脊髓轴突再生。
3. Conditioned medium of olfactory ensheathing cells promotes the functional recovery and axonal regeneration after contusive spinal cord injury [J] . Gu Mengchao, Gao Zhengchao, Li Xiaohui, Brain research . 2017,第Pta1期

机译：嗅鞘细胞的条件介质促进血型脊髓损伤后的功能恢复和轴突再生
4. Synthes Award for Resident Research in Spinal Cord Spinal Column Injury: Surgical Repair of the Injured Spinal Cord Using Biodegradable Polymer Implants to Facilitate Axon Regeneration [C] . Jonathan A. Friedman, Eric B. Lewellyn, Michael J Moore Congress of Neurological Surgeons . 2004

机译：脊髓脊柱损伤驻留研究综合奖：使用可生物降解的聚合物植入物的受损脊髓的手术修复，以促进轴突再生
5. 810 nm light treatment of acute spinal cord injury alters the immune response and improves axonal regeneration and functional recovery. [D] . Byrnes, Kimberly R. 2003

机译：810 nm光治疗急性脊髓损伤可改变免疫反应，并改善轴突再生和功能恢复。
6. Ex Vivo Adenoviral Vector-Mediated Neurotrophin Gene Transfer to Olfactory Ensheathing Glia: Effects on Rubrospinal Tract Regeneration Lesion Size and Functional Recovery after Implantation in the Injured Rat Spinal Cord [O] . Marc J. Ruitenberg, Giles W. Plant, Frank P. T. Hamers, 2003

机译：体外腺病毒载体介导的神经营养蛋白基因转移到嗅鞘神经胶质细胞：损伤大鼠脊髓植入后对脊髓神经束再生病变大小和功能恢复的影响。
7. Ex vivo adenoviral vector-mediated neurotrophin gene transfer to olfactory ensheathing glia: Effects on rubrospinal tract regeneration, lesion size, and functional recovery after implantation in the injured rat spinal cord [O] . Ruitenberg Marc J., Plant Giles W., Hamers Frank P.T., 2003

机译：体外腺病毒载体介导的神经营养蛋白基因转移到嗅鞘神经胶质细胞：损伤鼠脊髓植入后对脊髓锥体束再生，病变大小和功能恢复的影响
8. 810 NM Light Treatment of Acute Spinal Cord Injury Alters the Immune Response and Improves Axonal Regeneration and Functional Recovery [R] . Byrnes, K. R. 2003

机译：810 Nm轻度治疗急性脊髓损伤改变免疫反应并改善轴突再生和功能恢复

Ex vivo non-viral vector-mediated neurotrophin-3 gene transfer to olfactory ensheathing glia: effects on axonal regeneration and functional recovery after implantation in rats with spinal cord injury

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