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Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin

机译：慢病毒介导的胶质细胞源性神经营养因子在骨髓基质细胞中的过表达及其对乳腺素损伤的PC12细胞的神经保护作用

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摘要

ObjectiveTo construct recombinant lentiviral vectors for gene delivery of the glial cell line-derived neurotrophic factor (GDNF), and evaluate the neuroprotective effect of GDNF on lactacystin-damaged PC12 cells by transfecting it into bone marrow stromal cells (BMSCs).

机译：目的构建用于基因表达胶质细胞源性神经营养因子（GDNF）的重组慢病毒载体，并通过将其转染骨髓基质细胞（BMSCs）评估GDNF对乳腺素损伤的PC12细胞的神经保护作用。

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期刊名称 Neuroscience Bulletin
作者
Ya-Ru Su; Jian Wang; Jian-Jun Wu; Yan Chen; Yu-Ping Jiang;
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作者单位

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年(卷),期 2007(23),2
年度 2007
页码 67–74
总页数 8
原文格式 PDF
正文语种
中图分类神经科学;
关键词
Parkinson’s disease proteasome inhibitor glial cell line-derived neurotrophic factor lentivirus gene therapy bone marrow stromal cells;

机译：帕金森氏病;蛋白酶体抑制剂;神经胶质细胞源性神经营养因子;慢病毒;基因治疗;骨髓基质细胞;

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专利

1. Glial cell line-derived neurotrophic factor in bone marrow stromal cells of rat. [J] . Ye M, Chen S, Wang X, Neuroreport . 2005,第6期

机译：大鼠骨髓基质细胞中胶质细胞源性神经营养因子。
2. Neuroprotective effects of bone marrow stem cells overexpressing glial cell line-derived neurotrophic factor on rats with intracerebral hemorrhage and neurons exposed to hypoxia/reoxygenation. [J] . Yang C, Zhou L, Gao X, Neurosurgery . 2011,第3期

机译：过度表达神经胶质细胞源性神经营养因子的骨髓干细胞对脑出血和缺氧/复氧神经元的神经保护作用。
3. Glial cell line-derived neurotrophic factor-secreting genetically modified human bone marrow-derived mesenchymal stem cells promote recovery in a rat model of Parkinson's disease. [J] . Glavaski Joksimovic A, Virag T, Mangatu TA, Journal of Neuroscience Research . 2010,第12期

机译：胶质细胞源性神经营养因子分泌的基因修饰的人骨髓源性间充质干细胞可促进帕金森氏病大鼠模型的恢复。
4. Therapeutic time window of glial cell line-derived neurotrophic factor after transient middle cerebral artery occlusion in rat [C] . W.R. Zhang, K. Sato, M. Iwai, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：大鼠瞬时中脑动脉闭塞后胶质细胞系衍生神经营养因子的治疗时间窗
5. Regeneration and plasticity of descending propriospinal neurons after transplantation of Schwann cells overexpressing glial cell line-derived neurotrophic factor following thoracic spinal cord injury in adult rats. [D] . Deng, Lingxiao. 2015

机译：成年大鼠胸脊髓损伤后过量表达神经胶质细胞源性神经营养因子的雪旺细胞移植后降落脊髓原神经元的再生和可塑性。
6. Intrathecal injection of lentivirus-mediated glial cell line-derived neurotrophic factor RNA interference relieves bone cancer-induced pain in rats [O] . Fu-fen Meng, Yang Xu, Qi-qin Dan, 2015

机译：鞘内注射慢病毒介导的神经胶质细胞源性神经营养因子RNA干扰减轻大鼠骨癌引起的疼痛
7. Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin [O] . Ya-Ru Su, Jian Wang, Jian-Jun Wu, 2007

机译：乳晕基质细胞中慢病毒介导的胶质细胞介导的神经营养因子的过度表达及其对乳酸乳酸损坏的PC12细胞的神经保护作用

Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystin

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