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Involvement of MAPK/ERK kinase-ERK pathway in exogenous bFGF-induced Egr-1 binding activity enhancement in anoxia-reoxygenation injured astrocytes

机译：MAPK / ERK激酶-ERK通路参与外源性bFGF诱导的缺氧-复氧损伤星形胶质细胞Egr-1结合活性的增强

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ObjectiveIntravenous administration of basic fibroblast growth factor (bFGF) is effective to reduce the volume of cerebral infract due to ischemia. This study was designed to investigate the molecular mechanism, especially the signal transduction pathways, involved in this protective role of bFGF.

机译：目的静脉注射碱性成纤维细胞生长因子（bFGF）可有效减少缺血引起的脑梗塞。本研究旨在研究参与bFGF保护作用的分子机制，尤其是信号转导途径。

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期刊名称 Neuroscience Bulletin
作者
Ying Liu; Jin-Biao Lu; Qi Chen; Zhu-Rong Ye;
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作者单位

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年(卷),期 2007(23),4
年度 2007
页码 221–228
总页数 8
原文格式 PDF
正文语种
中图分类神经科学;
关键词
extracellular signal-regulated kinase mitogen-activated protein kinase free radicals fibroblast growth factor 2 early growth response protein 1 astrocyte;

机译：细胞外信号调节激酶;促分裂原活化蛋白激酶;自由基;成纤维细胞生长因子2;早期生长反应蛋白1;星形胶质细胞;

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专利

1. Egr-1 upregulates OPN through direct binding to its promoter and OPN upregulates Egr-1 via the ERK pathway [J] . Qi-Feng Liu, Hong-Wei Yu, Gui-Nan Liu Molecular and Cellular Biochemistry . 2009,第1a2期

机译：Egr-1通过直接与其启动子结合而上调OPN，而OPN通过ERK途径上调Egr-1
2. Egr-1 upregulates OPN through direct binding to its promoter and OPN upregulates Egr-1 via the ERK pathway. [J] . Liu QF, Yu HW, Liu GN Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2009,第1a2期

机译：Egr-1通过直接与其启动子结合而上调OPN，而OPN通过ERK途径上调Egr-1。
3. Egr-1 upregulates OPN through direct binding to its promoter and OPN upregulates Egr-1 via the ERK pathway. [J] . Liu QF, Yu HW, Liu GN Molecular and Cellular Biochemistry: An International Journal for Chemical Biology . 2009,第1a2期

机译：EGR-1通过直接结合其启动子和OPN通过ERK途径将OPN上调OPN。
4. Granulocyte colony -stimulating factor induces egr-1 up-regulation in myeloid cells through a MEK/ERK-dependent pathway and through interaction of serum response element -binding proteins [D] . Mora-Garcia, Patricia 2002

机译：粒细胞集落刺激因子通过MEK / ERK依赖性途径以及血清反应因子结合蛋白的相互作用诱导髓样细胞中的egr-1上调。
5. HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma [O] . Wei-Min Wang, Yang Xu, Yao-Hui Wang, 2017

机译：HOXB7通过bFGF诱导的MAPK / ERK途径激活促进肿瘤进展并提示肝细胞癌预后不良
6. HOXB7 promotes tumor progression via bFGF-induced activation of MAPK/ERK pathway and indicated poor prognosis in hepatocellular carcinoma [O] . Wei-Min Wang, Yang Xu, Yao-Hui Wang, 2017

机译：HoxB7通过BFGF诱导的MAPK / ERK途径激活促进肿瘤进展，并表明肝细胞癌预后差

Involvement of MAPK/ERK kinase-ERK pathway in exogenous bFGF-induced Egr-1 binding activity enhancement in anoxia-reoxygenation injured astrocytes

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