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The cellular basis of fetal endoplasmic reticulum stress and oxidative stress in drug-induced neurodevelopmental deficits

机译:药物引起的神经发育缺陷中胎儿内质网应激和氧化应激的细胞基础

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摘要

Prenatal substance exposure is a growing public health concern worldwide. Although the opioid crisis remains one of the most prevalent addiction problems in our society, abuse of cocaine, methamphetamines, and other illicit drugs, particularly amongst pregnant women, are nonetheless significant and widespread. Evidence demonstrates prenatal drug exposure can affect fetal brain development and thus can have long-lasting impact on neurobehavioral and cognitive performance later in life. In this review, we highlight research examining the most prevalent drugs of abuse and their effects on brain development with a focus on endoplasmic reticulum stress and oxidative stress signaling pathways. A thorough exploration of drug-induced cellular stress mechanisms during prenatal brain development may provide insight into therapeutic interventions to combat effects of prenatal drug exposure.
机译:产前物质暴露是全球范围内日益关注的公共卫生问题。尽管阿片类药物危机仍然是我们社会上最普遍的成瘾问题之一,但可卡因,甲基苯丙胺和其他非法药物的滥用,尤其是在孕妇中,仍然很普遍。有证据表明,产前药物暴露会影响胎儿的大脑发育,从而对生命后期的神经行为和认知表现产生长期影响。在这篇综述中,我们重点研究了最普遍的滥用药物及其对大脑发育的影响,重点是内质网应激和氧化应激信号通路。在产前大脑发育过程中对药物诱导的细胞应激机制的彻底研究可能会为治疗干预措施提供见识,以对抗产前药物暴露的影响。

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