Loss of host-derived osteopontin creates a glioblastoma-promoting microenvironment

摘要

BackgroundMicroglia and periphery-derived monocytes infiltrate human and mouse glioblastoma and their density is positively correlated with malignancy. Using microarray and RNA sequencing, we have previously shown that glioblastoma-associated microglia/monocytes (GAMs) express osteopontin/SPP1.