P05.26 Efficacy and tolerability of high dose chemotherapy with autologous stem cell rescue after surgery in patients with congenital brain tumors

摘要

BackgroundCongenital malignant brain tumors are extremely rare characterized by a poor prognosis. This could be due to a massive size of these tumors when they are diagnosed, the surgical difficulties and the lack of consolidated therapeutic approaches. Being radiotherapy not recommend for very young patients, the most favorable outcome is correlated to the gross total resection. We evaluated genetic characteristics, response rate, progression-free survival (PFS), and overall survival (OS) of high-dose chemotherapy and autologous stem cell transplant (ASCT) after surgery of infants with congenital brain malignancy.