P04.82 18F-FET and 18F-FAZA PET based radiotherapy of F98 glioblastoma rats

摘要

IntroductionGlioblastoma (GB) is the most common primary malignant brain tumor in adults. The standard of care consists of maximal possible surgical resection with concomitant radiation therapy (RT) and temozolomide (TMZ). Currently the target volume delineation for RT is based on CT and MRI. In this study we investigated the feasibility of incorporating PET for guiding RT and the impact on treatment outcome by applying subvolume boosting to a [¹⁸F]-FAZA or [¹⁸F]-FET defined tumor part.