P04.25 Expression and prognostic value of the transcription factors EGR1 and EGR3 in gliomas

摘要

BackgroundGliomas are the most frequent primary brain tumors. For the most malignant glioma - the glioblastoma - the median survival is only 15 months. Few prognostic biomarkers are useful in daily practice, and new markers are urgently needed. EGR1 and EGR3 are transcription factors involved in the regulation of mitogenesis, cell differentiation, and EGR3 has also been suggested to be involved in cell migration. Both proteins have shown prognostic potential in other cancers. The aim of this study was to investigate the expression of EGR1 and EGR3, and investigate their prognostic value in gliomas.