P01.126 Frequent Tp53 and ATRX/DAXX gene alterations in giant cell IDH-Wildtype Glioblastomas

摘要

BackgroundThe 2016 updated World Health Organization (WHO) classification system recognizes the morphological variant giant cell glioblastoma (GBM) as one rare variant of IDH-wildtype (IDH-wt) GBM. This variant account for <1% of all GBMs, occurs in young adults patients and have a slightly better prognosis that ordinary IDH-wt GBM. Histologically, it is characterized by the presence of bizarre and numerous multinucleated giant cells. The lack of a more precise definition of this morphological variant makes that sometimes the giant cell component is not taken into account, even though some evidences may suggest that it may be clinically relevant. This variant has not been characterized yet by specific genetic biomarkers such as other variants of GBM, e.g. epithelioid GBM with BRAF mutations or secondary GBM with IDH mutations. The purpose of our study is to determine whether there is a molecular genetic base underlying the giant cell morphological variant of GBM.