PDTM-26. TUMOR TREATING FIELDS (TTFIELDS) HAVE ANTI-PROLIFERATIVE EFFECTS ON PEDIATRIC BRAIN TUMOR CELL LINES AT CLINICALLY DELIVERABLE FIELD SETTINGS

摘要

INTRODUCTIONOverall survival remains poor for some childhood brain tumors, particularly high-grade gliomas and recurrent ependymoma. Pre-clinical studies have shown efficacy of electrical tumor treating fields (TTFields) on high-grade glioma cell lines. TTFields have been approved for adult glioblastoma (GBM) patients in combination with chemo-radiotherapy. The lack of overlapping toxicities associated with Optune has made TTFields an attractive treatment strategy for poor prognosis brain tumors.