Half-Sandwich Ru(II) Halogenido Valproato and 4-Phenylbutyrato Complexes Containing 22′-Dipyridylamine: Synthesis Characterization Solution Chemistry and In Vitro Cytotoxicity

摘要

Halogenido and carboxylato Ru(II) half-sandwich complexes of the general composition [Ru(η⁶-p-cym)(dpa)X]PF6 (>1–>5) were prepared and thoroughly characterized with various techniques (e.g., mass spectrometry, NMR spectroscopy and X-ray analysis); dpa = 2,2′-dipyridylamine; p-cym = p-cymene; X = Cl⁻ (for >1), Br⁻ (for >2), I⁻ (for >3), valproate(1−) (for >4) or 4-phenylbutyrate(1−) (for >5). A single-crystal X-ray analysis showed a pseudo-octahedral piano-stool geometry of [Ru(η⁶-p-cym)(dpa)I]PF6 (>3), with a η⁶-coordinated p-cymene, bidentate N-donor dpa ligand and iodido ligand coordinated to the Ru(II) atom. The results of the ¹H-NMR solution behaviour studies proved that the complexes >1–>5 hydrolyse were in the mixture of solvents used (10% MeOD-d4/90% D2O). Complexes >1–>5 were in vitro inactive against the A2780 human ovarian carcinoma cell line, up to the highest tested concentration (IC50 > 100 μM).