Four New Cyclohexylideneacetonitrile Derivatives from the Hypocotyl of Mangrove (Bruguiera gymnorrhiza)

摘要

Four new cyclohexylideneacetonitrile derivatives >1–>4, named menisdaurins B–E, as well as three known cyclohexylideneacetonitrile derivatives—menisdaurin (>5), coclauril (>6), and menisdaurilide (>7)—were isolated from the hypocotyl of a mangrove (Bruguiera gymnorrhiza). The structures of the isolates were elucidated on the basis of extensive spectroscopic analysis. Compounds >1–>7 showed anti-Hepatitis B virus (HBV) activities, with EC50 values ranging from 5.1 ± 0.2 μg/mL to 87.7 ± 5.8 μg/mL.