A Novel 39-(123-Trioxocine)-Type Steroid of Rauia nodosa (Rutaceae)

摘要

A new natural product, a 3,9-(1,2,3-trioxocine)-type steroid, named rauianodoxy (>6), was isolated from Rauia nodosa, together with five steroids: sistostenone (>1), stigmastenone (>2), sitosterol (>3), stigmasterol (>4) and ergosterol peroxide (>5), one coumarin, O-geranylosthenol (>7), and three alkaloids, N-methylflindersine (>8), zantobungeanine (>9) and veprissine (>10). Compounds >5–>8 were isolated for the first time in the genus Rauia. These compounds were characterized on the basis of their spectral data, mainly one and two-dimensional NMR, and mass spectra, also involving comparison with the literature data. Theoretical studies at the DFT level reveal structural parameters for the 1,2,3-trioxole bridge compatible with known structures containing a similar group.