Carapanolides J–L from the Seeds of Carapa guianensis (Andiroba) and Their Effects on LPS-Activated NO Production

摘要

A novel gedunin and two novel phragmalin-type limonoids, named carapanolides J–L (compounds >1–>3) as well as a known gedunin-type limonoid >4 were isolated from the seeds of Carapa guianensis (andiroba). Their structures were determined on the basis of 1D and 2D NMR spectroscopy and HRFABMS. Compounds >1–>4 were evaluated for their effects on the production of NO in LPS-activated mouse peritoneal macrophages.