The Knoevenagel-Doebner Reaction on 12-O-(222-Trichloroethylidene) Derivatives of D-Gluco- and D-Manno- furanose

摘要

The synthesis of new α,β-unsaturated furanuronic acid derivatives of α-gluco- (>3), β-gluco- (>6) and β-manno-chloraloses (>9) via a convenient one pot procedure using the Knoevenagel-Doebner reaction approach are described. The dialdofuranose derivatives were reacted with malonic acid under Knoevenagel-Doebner reaction conditions and (E)-α,β-unsaturated furanuronic acid derivatives were obtained.