Synthesis and Antibacterial Activities of New Metronidazole and Imidazole Derivatives

摘要

New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds >7a-c were synthesized by the reaction of compounds >6a-c with hydrazine hydrate. Biimidazole esters >9a-c were converted into biimidazole hydrazide esters >10a-c. Compounds >7a-c and >10a-c were converted into a variety of derivatives.