A Novel Synthetic Approach to C-Glycosyl-d- and l-Alanines

摘要

C-Glycosyl-(S)- and (R)-alanines >12a and >12b were synthesized from the known β-C-glycoside >1. The nitrogen function was introduced by aza-Claisen rearrangement of the allylic thiocyanate >7, derived from the corresponding alcohol >6. The absolute configuration of the newly created chiral carbon center (C-3) was assigned by X-ray diffraction analysis of the intermediate 3(S)-isothiocyanato-d-glycero-d-galacto-decose >8a.