Synthesis of Conformationally Constrained Aryl- or Heteroaryl-piperazinyl Derivatives of Selected Imides as 5-HT1A Receptor Ligands

摘要

The preparation of a number of cyclic imide 5-HT1A receptor ligand derivatives has been described. Their structures were conformationally constrained by introducing rigid linkers containing unsaturated bonds or aromatic benzene rings. These compounds are expected to possess anxiolytic and antidepressant activity.