Reduced regional activity and functional connectivity withinsensorimotor network in Parkinson’s patients with restless legssyndrome

摘要

BackgroundRestless legs syndrome is an important sleep disturbance in Parkinson’s disease. Restless legs syndrome causes an urge to move the legs accompanying sensations which can be difficult to describe but include aching, burning, tingling, or crawling. However, the underlying pathophysiology of restless legs syndrome in Parkinson’s disease remains unknown and no imaging investigation has been conducted to explore its mechanism to date.