低频振幅结合功能连接对原发性甲亢患者感觉运动网络的功能MRI研究

摘要

Objective:To investigate the changes of ALFF (amplitude of low-frequency fluctuation) and FC (functional connectivity) in hyperthyroid patients with RS-fMRI (resting-state functional magnetic resonance imaging), and the relationships of the characteristics with emotional disorders, spontaneous brain resting activities, biochemical and biological characteristics.Materials and Methods:Twelve patients diagnosed with primary hyperthyroidism were collected in this study. Another 12 age-and-sex-matched healthy individuals served as control. Gathering fMRI scaned of all the subjects at their resting -state, using REST and DPARSF software to obtain each amplitude of low-frequency fluctuation (ALFF), then we used two samplet-test to discover the brain areas with significant differentiation of ALFF values. The brain areas were defined as regions of interest (ROI). ROI based functional connectivities (FC) were analyzed to explore some possible abnormalities. Results:Compared with controls, the ALFF of hyperthyroidism individuals was reduced in the bilateral caudate, and bilateral thalamus (P<0.001). In these brain regions, we find no correlation between ALFF and T3, T4 (P>0.05). In contrast with controls, hyperthyroid patients showed stronger FC between the left thalamus and both the bilateral precentral gyrus and bilateral postcentral gyrus (P<0.001), as well as between the right thalamus and both the right precentral gyrus and right postcentral gyrus (P<0.001).Conclusions:The present study shows that, functional demands between bilateral thalamus and sensorimotor network are higher in patients compared to controls. It is likely attributed to motor function deficit associated with metabolic impairment in these patients.%目的 采用低频振幅(amplitude of low frequency fluctuation,ALFF)与功能连接(functional connectivity,FC)相结合的方法 ,研究原发性甲状腺功能亢进患者静息状态下脑功能改变.材料与方法 12名未经治疗的甲亢患者为病例组,12名自愿接受扫描的健康人(年龄、性别无显著性差异)为对照组.采集所有被试静息态fMRI数据,采用REST及DPARSF软件分析原始数据,得出全脑ALFF,利用双样本t检验的方法 比较病例组和对照组ALFF的变化,并以两组间ALFF值有显著性差异的脑区为感兴趣区(regions of interest,ROI)校正后行FC分析.结果 与对照组相比,甲亢患者在双侧尾状核及双侧丘脑ALFF值降低(P<0.001).以上脑区的ALFF值均未发现与T3、T4有显著相关性(P>0.05).FC分析显示,左侧丘脑与双侧感觉运动区(包括中央前回、中央后回)FC增强(P<0.001);右侧丘脑与右侧中央前回及中央后回连接增强(P<0.001).结论 甲亢患者双侧丘脑的局部活动及其与大脑感觉运动网络的FC模式存在异常,增强的FC可能与代谢损伤所导致运动机能受损而使甲状腺功能异常患者有更强的功能需求有关.