In vivo optical imaging of integrin αV-β3 in mice using multivalent or monovalent cRGD targeting vectors

摘要

BackgroundThe cRGD peptide is a promising probe for early non-invasive detection of tumors. This study aimed to demonstrate how RAFT-c(-RGDfK-)4, a molecule allowing a tetrameric presentation of cRGD, improved cRGD-targeting potential using in vivo models of αVβ3-positive or negative tumors.