Quantitative autism symptom patterns recapitulate differential mechanisms of genetic transmission in single and multiple incidence families

摘要

BackgroundPrevious studies have demonstrated aggregation of autistic traits in undiagnosed family members of children with autism spectrum disorder (ASD), which has significant implications for ASD risk in their offspring. This study capitalizes upon a large, quantitatively characterized clinical-epidemiologic family sample to establish the extent to which family transmission pattern and sex modulate ASD trait aggregation.