Coaxial Electrohydrodynamic Atomization for the Production of Drug-Loaded Micro/Nanoparticles

摘要

Coaxial electrohydrodynamic atomization (CEHDA) presents a promising technology for preparing drug-loaded microanoparticles with core-shell structures. Recently, CEHDA has attracted tremendous attention based on its specific advantages, including precise control over particle size and size distribution, reduced initial burst release and mild preparation conditions. Moreover, with different needles, CEHDA can produce a variety of drug-loaded microanoparticles for drug delivery systems. In this review, we summarize recent advances in using double-layer structure, multilayer structure and multicomponent encapsulation strategies for developing microanoparticles. The merits of applying multiplexed electrospray sources for high-throughput production are also highlighted.