Interaction of Rh2(O2CCH3)4(H2O)2 and Rh2(O2CCH(OH)Ph)2(phen)2(H2O)2(O2C-CH(OH)Ph)2 With Sulfhydryl Compounds and Ceruloplasmin

摘要

The interaction of binuclear rhodium(II) complexes [Rh2(OOCCH3)4(H2O)2], [Rh2{OOCCH(OH)Ph}2(phen)2(H2O)2] {OOCCH(OH)Ph}2, [Rh2(OOCCH3)2(bpy)2(H2O)₂](OOCCH₃)₂ and [Rh₂Cl₂(OOCMe)₂(bpy)₂](3H₂O) with ceruloplasmin, cysteine, glutathione and coenzyme A have been investigated using. UV-Vis and CD spectroscopies. The complexes containing phen or bpy at pH = 7.4 and 4.0 are readily reduced with sulfhydryl compounds, while rhodium(II) acetate is relatively stable in these conditions. Complex [Rh₂{OOCCH(OH)Ph}₂(phen)₂(H₂O)₂] strongly changes structure of ceruloplasmin leading to the decrease of of α-helix content and loss of oxidase activity.