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Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is Improved by Elevated Fluid Shear Stress

机译：流体剪切应力升高可改善大鼠I动脉内皮结构和功能的年龄相关损伤

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BackgroundAging plays an important role in endothelial dysfunction. Fluid shear stress (FSS) can activate endothelial cells (ECs). Herein, we tested the hypothesis that this endothelial impairment could be improved by elevated FSS (EFSS) in aged rats.

机译：背景衰老在内皮功能障碍中起重要作用。流体剪切应力（FSS）可以激活内皮细胞（ECs）。在这里，我们测试了这一假设，即老年大鼠的FSS（EFSS）升高可以改善这种内皮损伤。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Liping Dong; Liaoying Gan; Hui Wang; Weijun Cai;
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作者单位

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年(卷),期 2019(25),-1
年度 2019
页码 5127–5136
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
Aged Endothelial Cells Nitric Oxide Synthase Type III Sirtuin 1;

机译：老化的内皮细胞;一氧化氮合酶III型;Sirtuin 1;

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专利

1. Chronic Hydralazine Improves Flow (Shear Stress)-Induced Endothelium-Dependent Dilation in Mouse Mesenteric Resistance Arteries in Vitro. [J] . Gorny D, Kubis N, Henrion D Microvascular Research: An International Journal . 2002 ,第1期

机译：慢性肼屈嗪改善了小鼠肠系膜抗性动脉的血流（剪切应力）诱导的内皮依赖性扩张。
2. NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries. [J] . Trott DW, Seawright JW, Luttrell MJ, Journal of applied physiology . 2011 ,第5期

机译：NAD（P）H氧化酶衍生的活性氧导致比目鱼饲料动脉中内皮依赖性扩张的年龄相关损伤。
3. Short-term increases in pressure and shear stress attenuate age-related declines in endothelial function in skeletal muscle feed arteries [J] . Seawright John W., Luttrell Meredith, Trache Andreea, European journal of applied physiology . 2016 ,第7期

机译：压力和切应力的短期增加可减轻骨骼肌饲料动脉中与年龄相关的内皮功能下降
4. Morphological and acoustical changes of endothelium by fluid shear stress [C] . Saijo, Y., Sasaki, . 1998

机译：流体剪切应力引起的内皮形态和声学变化
5. Effects of tensile spatial shear stress gradients on porcine iliac artery permeability and endothelial cell biology. [D] . LaMack, Jeffrey Alan. 2006

机译：拉伸空间剪切应力梯度对猪动脉通透性和内皮细胞生物学的影响。
6. NAD(P)H oxidase-derived reactive oxygen species contribute to age-related impairments of endothelium-dependent dilation in rat soleus feed arteries [O] . Daniel W. Trott, John W. Seawright, Meredith J. Luttrell, -1

机译：NAD（P）H氧化酶衍生的活性氧导致比目鱼饲料动脉内皮依赖性扩张的年龄相关损伤
7. Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is Improved by Elevated Fluid Shear Stress [O] . Liping Dong, Liaoying Gan, Hui Wang, 2019

机译：通过升高的流体剪切应力，改善了大鼠髂动脉内皮的年龄相关的结构和功能损伤

Age-Related Impairment of Structure and Function of Iliac Artery Endothelium in Rats Is Improved by Elevated Fluid Shear Stress

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