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A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial)

机译：奥沙利铂联合口服S-1和骨盆放疗对局部晚期直肠癌患者的I期剂量递增研究（SHOGUN试验）

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摘要

BackgroundThe objective of this phase I study was to determine the maximum tolerated dose (MTD) and recommended dose (RD) of preoperative chemoradiotherapy (CRT) with S-1 plus oxaliplatin in patients with locally advanced rectal cancer.

机译：背景I期研究的目的是确定局部晚期直肠癌患者使用S-1加奥沙利铂进行术前放化疗（CRT）的最大耐受剂量（MTD）和推荐剂量（RD）。

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期刊名称 Radiation Oncology (London England)
作者
Soichiro Ishihara; Satoshi Matsusaka; Keisaku Kondo; Hisanaga Horie; Keisuke Uehara; Masahiko Oguchi; Keiko Murofushi; Masashi Ueno; Nobuyuki Mizunuma; Taijyu Shinbo; Daiki Kato; Junji Okuda; Yojiro Hashiguchi; Masanori Nakazawa; Eiji Sunami; Kazushige Kawai; Hideomi Yamashita; Tohru Okada; Yuichi Ishikawa; Toshifusa Nakajima; Toshiaki Watanabe;
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作者单位

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年(卷),期 2015(10),-1
年度 2015
页码 24
总页数 7
原文格式 PDF
正文语种
中图分类肿瘤学;放射医学;影像诊断学;
关键词
Rectal cancer Chemoradiotherapy Phase I study Oxaliplatin S-1;

机译：直肠癌;放化疗;I期研究;奥沙利铂;S-1;

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专利

1. 奥沙利铂和卡培他滨联合贝伐单抗加放疗的新辅助方案治疗局部晚期直肠癌:单中心Ⅱ期研究结果 [J] . Xin Yu, De-sen Wan, Pei-rong Ding, 癌症（英文版） . 2018,第008期
2. A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial) [J] . Soichiro Ishihara, Satoshi Matsusaka, Keisaku Kondo, Radiation oncology . 2015,第1期

机译：奥沙利铂联合口服S-1和骨盆放射治疗局部晚期直肠癌患者的I期剂量递增研究（SHOGUN试验）
3. A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial) [J] . Soichiro Ishihara, Satoshi Matsusaka, Keisaku Kondo, Radiation oncology . 2015,第1期

机译：奥沙利铂联合口服S-1和骨盆放射治疗局部晚期直肠癌患者的I期剂量递增研究（SHOGUN试验）
4. A phase I dose escalation study of continuous oral capecitabine in combination with oxaliplatin and pelvic radiation (XELOX-RT) in patients with locally advanced rectal cancer. [J] . Glynne Jones R, Sebag Montefiore D, Maughan TS, Annals of oncology: official journal of the European Society for Medical Oncology . 2006,第1期

机译：局部晚期直肠癌患者连续口服卡培他滨联合奥沙利铂和骨盆放疗（XELOX-RT）的I期剂量递增研究。
5. Neoadjuvant treatment in rectal cancer: do we always need radiotherapy-or can we risk assess locally advanced rectal cancer better? [C] . Rob Glynne-Jones St. Gallen EORTC Gastrointestinal Cancer Conference . 2012

机译：Neoadjuvant在直肠癌中治疗：我们总是需要放射治疗 - 或者我们是否可以更好地评估当地先进的直肠癌？
6. Intenzivnej?e neoadjuvantno zdravljenje lokalno napredovalnega raka danke =Intensified neoadjuvant treatment of locally advanced rectal cancer [D] . Golo, Danijela. 2018

机译：强烈的Neoadjuvant治疗局部晚期癌症射线=加强Neoadjuvant治疗局部晚期直肠癌
7. Phase II Trial of Preoperative Radiation With Concurrent Capecitabine Oxaliplatin and Bevacizumab Followed by Surgery and Postoperative 5-Fluorouracil Leucovorin Oxaliplatin (FOLFOX) and Bevacizumab in Patients With Locally Advanced Rectal Cancer: 5-Year Clinical Outcomes ECOG-ACRIN Cancer Research Group E3204 [O] . Jerome C. Landry, Yang Feng, Roshan S. Prabhu, 2015

机译：局部晚期直肠癌患者术前放开卡培他滨奥沙利铂和贝伐单抗联合手术及术后5-氟尿嘧啶白叶素奥沙利铂（FOLFOX）和贝伐单抗的术前放疗的II期试验：5年临床结果ECOG-ACRIN癌症研究E3204组
8. A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial) [O] . Soichiro Ishihara, Satoshi Matsusaka, Keisaku Kondo, 2015

机译：奥沙利铂联合口服S-1和骨盆放疗对局部晚期直肠癌患者的I期剂量递增研究（SHOGUN试验）

A phase I dose escalation study of oxaliplatin plus oral S-1 and pelvic radiation in patients with locally advanced rectal cancer (SHOGUN trial)

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