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Factors affecting treatment outcomes in drug-resistant tuberculosis cases in the Northern Cape South Africa

机译:南非北开普省耐药结核病例中影响治疗结果的因素

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摘要

The Northern Cape Province has low cure rates (21%) for multidrug-resistant tuberculosis (TB). We audited the programme to identify factors affecting treatment outcomes. Cases admitted to two drug-resistant TB units from 2007 to 2009 had data extracted from clinical folders. Unfavourable treatment outcomes were found in 58% of the 272 cases. A multivariable regression analysis found that male sex was associated with unfavourable outcome (P = 0.009). Weight at diagnosis (P < 0.001) and oral drug adherence (P < 0.001) were also associated with an unfavourable outcome; however, injectable drug adherence was not (P = 0.395). Positive baseline smear and human immunodeficiency virus positive status were not associated with unfavourable outcome. Shorter, more patient-friendly regimens may go a long way to improving adherence and outcomes.
机译:北开普省对耐多药结核病(TB)的治愈率很低(21%)。我们审核了该计划,以确定影响治疗结果的因素。从2007年到2009年,进入两个耐药结核病单位的病例的数据来自临床资料夹。在272例病例中有58%发现不良的治疗结果。多变量回归分析发现,男性与不良结局有关(P = 0.009)。诊断时体重(P <0.001)和口服药物依从性(P <0.001)也与不良预后相关;但是,可注射药物的依从性不佳(P = 0.395)。基线涂片阳性和人类免疫缺陷病毒阳性状态与不良预后无关。更短,更患者友好的治疗方案可能会大大改善依从性和治疗效果。

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