BackgroundThe recommended daptomycin dosage is 4 or 6 mg/kg/day for the treatment of complicated skin and soft tissue infections or for Staphylococcus aureus bacteremia, endocarditis, and osteomyelitis. Every other day administration is usually recommended for patients with mild to moderate renal impairment. Higher doses (>6 mg/kg/day) have been explored as a possible alternative. Daptomycin is considered a safe anti-methicillin-resistant S. aureus (MRSA) drug, although renal dysfunction may be worsened. In this paper we report on three patients with chronic renal failure who received a higher dose of daptomycin daily for successful treatment for MRSA bacteremia, MRSA osteomyelitis, and methicillin-resistant S. epidermidis (MRSE) endocarditis.
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机译：背景达托霉素的推荐剂量为4或6 mg / kg /天，用于治疗复杂的皮肤和软组织感染或金黄色葡萄球菌菌血症，心内膜炎和骨髓炎。通常建议轻度至中度肾功能不全的患者隔天给药。已经探索出更高的剂量（> 6 mg / kg /天）作为可能的替代方法。达托霉素被认为是一种安全的抗甲氧西林金黄色葡萄球菌（MRSA）药物，尽管肾功能不全可能会恶化。在本文中，我们报告了三例慢性肾脏衰竭患者，这些患者每天接受更高剂量的达托霉素用于成功治疗MRSA菌血症，MRSA骨髓炎和耐甲氧西林表皮葡萄球菌（MRSE）心内膜炎。
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