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Model Selection and Evaluation Based on Emerging Infectious Disease Data Sets including A/H1N1 and Ebola

机译:基于包括A / H1N1和埃博拉病毒在内的新兴传染病数据集的模型选择和评估

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摘要

The aim of the present study is to apply simple ODE models in the area of modeling the spread of emerging infectious diseases and show the importance of model selection in estimating parameters, the basic reproduction number, turning point, and final size. To quantify the plausibility of each model, given the data and the set of four models including Logistic, Gompertz, Rosenzweg, and Richards models, the Bayes factors are calculated and the precise estimates of the best fitted model parameters and key epidemic characteristics have been obtained. In particular, for Ebola the basic reproduction numbers are 1.3522 (95% CI (1.3506, 1.3537)), 1.2101 (95% CI (1.2084, 1.2119)), 3.0234 (95% CI (2.6063, 3.4881)), and 1.9018 (95% CI (1.8565, 1.9478)), the turning points are November 7,November 17, October 2, and November 3, 2014, and the final sizes until December 2015 are 25794 (95% CI (25630, 25958)), 3916 (95% CI (3865, 3967)), 9886 (95% CI (9740, 10031)), and 12633 (95% CI (12515, 12750)) for West Africa, Guinea, Liberia, and Sierra Leone, respectively. The main results confirm that model selection is crucial in evaluating and predicting the important quantities describing the emerging infectious diseases, and arbitrarily picking a model without any consideration of alternatives is problematic.
机译:本研究的目的是在模拟新兴传染病传播的领域中应用简单的ODE模型,并显示模型选择在估计参数,基本繁殖数量,转折点和最终大小方面的重要性。为了量化每个模型的合理性,给定数据以及包括Logistic,Gompertz,Rosnzweg和Richards模型在内的四个模型的集合,计算了贝叶斯因子并获得了最佳拟合模型参数和关键流行特征的精确估计。 。特别是对于埃博拉,基本繁殖数是1.3522(95%CI(1.3506,1.3537)),1.2101(95%CI(1.2084,1.2119)),3.0234(95%CI(2.6063,3.4881))和1.9018(95) %CI(1.8565,1.9478)),拐点为2014年11月7日,11月17日,10月2日和2014年11月3日,到2015年12月的最终大小为25794(95%CI(25630,25958)),3916(西非,几内亚,利比里亚和塞拉利昂的95%CI(3865,3967)),9886(95%CI(9740,10031))和12633(95%CI(12515,12750))。主要结果证实,模型选择对于评估和预测描述新兴传染病的重要数量至关重要,并且在不考虑替代方案的情况下随意选择模型是有问题的。

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