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Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

机译：5公斤以下未接受复杂治疗的蒿甲醚-氟美汀治疗的恶性疟原虫疟疾的婴儿中蒿甲醚和双氢青蒿素的全身暴露增加

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BackgroundArtemether-lumefantrine (AL) dispersible formulation was developed for the treatment of uncomplicated Plasmodium falciparum malaria in infants and children weighing 5 to <35 kg. However, there are no clinical studies with artemisinin-based combination therapy in infants <5 kg.

机译：背景技术开发了蒿甲醚-荧光黄酮（AL）的可分散制剂，用于治疗体重5至<35 kg的婴儿和儿童的单纯性恶性疟原虫疟疾。但是，目前尚无针对5公斤以下婴儿的基于青蒿素的联合疗法的临床研究。

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期刊名称 Malaria Journal
作者
Alfred B Tiono; Halidou Tinto; Maroufou J Alao; Martin Meremikwu; Antoinette Tshefu; Bernhards Ogutu; Alphonse Ouedraogo; Moussa Lingani; Marc Cousin; Gilbert Lefèvre; Jay Prakash Jain; Stephan Duparc; Kamal Hamed;
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作者单位

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年(卷),期 2015(14),-1
年度 2015
页码 157
总页数 10
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
关键词
Artemether-lumefantrine Dispersible Efficacy Infants Pharmacokinetics Safety 5 kg body weight;

机译：蒿甲醚-荧光黄素;分散性;功效;婴儿;药代动力学;安全性;5公斤体重;

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1. Increased systemic exposures of artemether and dihydroartemisinin in infants under 5?kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem?) [J] . Alfred B Tiono, Halidou Tinto, Maroufou J Alao, Malaria Journal . 2015,第S1期

机译：5公斤以下未接受蒿甲醚-氟美汀治疗的单纯性恶性疟原虫疟疾的婴儿中，蒿甲醚和双氢青蒿素的全身暴露增加
2. Comparative clinical trial of two-fixed combinations dihydroartemisinin-napthoquine-trimethoprim (DNP) and artemether-lumefantrine (Coartem/Riamet) in the treatment of acute uncomplicated falciparum malaria in Thailand. [J] . Krudsood S, Chalermrut K, Pengruksa C, The Southeast Asian journal of tropical medicine and public health . 2003,第2期

机译：两种固定的双氢青蒿素-萘醌-甲氧苄氨嘧啶（DNP）和蒿甲醚-卢美他汀（Coartem / Riamet）联合治疗泰国急性单纯性恶性疟疾的比较临床试验。
3. Assessment of therapeutic efficacy and safety of artemether-lumefantrine (Coartem?) in the treatment of uncomplicated Plasmodium falciparum malaria patients in Bahir Dar district, Northwest Ethiopia: an observational cohort study [J] . Yehenew A. Ebstie, Ahmed Zeynudin, Tefera Belachew, Malaria Journal . 2015,第3期

机译：埃塞俄比亚西北部巴希尔达尔地区蒿甲醚-卢美他汀（Coartem？）治疗单纯性恶性疟原虫疟疾患者的疗效和安全性评估：一项队列研究
4. Shifting to Plasmodium vivax dominance at highlands of Ethiopia following the countrywide intensive use of artemether-lumefantrine throughout endemic areas since 2005: Can we neglect the role of climate and relapse cases? [C] . Gemeda A. W., Wakgari D., Ahmed A., World Congress on Public Health . 2013

机译：自2005年以来，埃塞俄比亚高地在埃塞俄比亚高地迁移到埃塞俄比亚高地的疟原虫优惠占优势：我们可以忽视气候和复发案件的作用吗？
5. Characterization of the antibody response to Plasmodium falciparum in infants living in a malaria-endemic area [D] . Fouda, Genevieve Giny Amou'ou 2006

机译：疟疾流行地区婴儿对恶性疟原虫抗体反应的特征
6. COMPARATIVE CLINICAL TRIAL OF TWO-FIXED COMBINATIONS DIHYDROARTEMISININ-NAPTHOQUINE-TRIMETHOPRIM (DNP®) AND ARTEMETHER-LUMEFANTRINE (COARTEM®/RIAMET®) IN THE TREATMENT OF ACUTE UNCOMPLICATED FALCIPARUM MALARIA IN THAILAND [O] . S Krudsood, K Chalermrut, C Pengruksa, -1

机译：两种固定组合的双氢青蒿素-萘醌-三甲-（DNP®）和Artemether-lumefantrine（COARTEM®/RIAMET®）在泰国治疗急性并发症的恶性疟疾的比较临床试验
7. Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®) [O] . Alfred B Tiono, Halidou Tinto, Maroufou J Alao, 2015

机译：5公斤以下未接受复杂治疗的蒿甲醚-氟美汀治疗的恶性疟原虫疟疾的婴儿中蒿甲醚和双氢青蒿素的全身暴露增加

Increased systemic exposures of artemether and dihydroartemisinin in infants under 5 kg with uncomplicated Plasmodium falciparum malaria treated with artemether-lumefantrine (Coartem®)

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