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Resistin Visfatin Adiponectin and Leptin: Risk of Breast Cancer in Pre- and Postmenopausal Saudi Females and Their Possible Diagnostic and Predictive Implications as Novel Biomarkers

机译:ResistinVisfatinAdiponectin和Leptin:绝经前和绝经后的沙特女性患乳腺癌的风险及其作为新的生物标记物的诊断和预测意义

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摘要

The mechanisms of obesity-induced breast carcinogenesis are not clear. One hypothesis is that high levels of adipokines could promote breast cancer (BC) development. The aim of this study was to investigate the correlation of resistin, visfatin, adiponectin, and leptin with BC risk in pre- and postmenopausal females. A total of 82 BC newly diagnosed and histologically confirmed patients and 68 age and BMI matched healthy controls were enrolled. Both groups were subdivided into post- and premenopausal subgroups. Resistin, visfatin, adiponectin, and leptin were measured by ELISA. There were significantly higher levels of leptin, resistin, and visfatin in postmenopausal BC patients than their respective controls. Only in postmenopausal subgroups, leptin, resistin, and visfatin levels were positively correlated with TNM staging, tumor size, lymph node (LN) metastasis, and histological grading. In postmenopausal females, multivariate logistic regression analysis revealed that adiponectin, leptin, visfatin, and resistin were risk factors for BC. Our results suggested that serum resistin, leptin, adiponectin, and visfatin levels as risk factors for postmenopausal BC may provide a potential link with clinicopathological features and are promising to be novel biomarkers for postmenopausal BC.
机译:肥胖引起的乳腺癌致癌机制尚不清楚。一种假设是高水平的脂肪因子可能促进乳腺癌(BC)的发展。这项研究的目的是调查绝经前和绝经后女性抵抗素,visfatin,脂联素和瘦素与BC风险的相关性。总共入选了82例新诊断和组织学确诊的BC患者以及68例年龄和BMI匹配的健康对照者。两组均分为绝经后和绝经前两个亚组。抵抗素,visfatin,脂联素和瘦素通过ELISA测定。绝经后BC患者的瘦素,抵抗素和visfatin的水平明显高于各自的对照组。仅在绝经后的亚组中,瘦素,抵抗素和visfatin水平与TNM分期,肿瘤大小,淋巴结转移和组织学分级呈正相关。在绝经后女性中,多因素logistic回归分析显示脂联素,瘦素,维斯法汀和抵抗素是BC的危险因素。我们的结果表明,血清抵抗素,瘦素,脂联素和visfatin水平是绝经后BC的危险因素,可能与临床病理特征存在潜在联系,并有望成为绝经后BC的新型生物标志物。

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