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MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs

机译：MicroRNA-133b靶向谷胱甘肽S-转移酶π表达以提高卵巢癌细胞对化疗药物的敏感性

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BackgroundAccumulating studies reveal that aberrant microRNA (miRNA) expression can affect the development of chemotherapy drug resistance by modulating the expression of relevant target proteins. The aim of this study was to investigate the role of miR-133b in the development of drug resistance in ovarian cancer cells.

机译：背景大量研究表明，异常的microRNA（miRNA）表达可通过调节相关靶蛋白的表达来影响化疗药物耐药性的发展。这项研究的目的是研究miR-133b在卵巢癌细胞耐药性发展中的作用。

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期刊名称 Drug Design Development and Therapy
作者
Shuo Chen; Jin-Wen Jiao; Kai-Xuan Sun; Zhi-Hong Zong; Yang Zhao;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 5225–5235
总页数 11
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
cisplatin drug resistance ovarian cancer cells paclitaxel;

机译：顺铂;耐药性;卵巢癌细胞;紫杉醇;

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专利

1. MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs [J] . Shuo Chen, Jin-Wen Jiao, Kai-Xuan Sun, Drug Design, Development and Therapy . 2015,第5期

机译：MicroRNA-133b靶向谷胱甘肽S-转移酶π表达，以提高卵巢癌细胞对化疗药物的敏感性
2. Mood stabilizing drugs lamotrigine and olanzapine increase expression and activity of glutathione S-transferase in primary cultured rat cerebral cortical cells. [J] . Bakare A, Shao L, Cui J Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2009,第1期

机译：情绪稳定药物拉莫三嗪和奥氮平可增加原代培养的大鼠大脑皮层细胞中谷胱甘肽S-转移酶的表达和活性。
3. Ectopic over-expression of miR-429 induces mesenchymal-to-epithelial transition (MET) and increased drug sensitivity in metastasizing ovarian cancer cells [J] . Wang Lijuan, Mezencev Roman, Svajdler Marian, Gynecologic Oncology: An International Journal . 2014,第1期

机译：在转移性卵巢癌细胞中，miR-429的异位过表达诱导间质向上皮转化（MET）并增加了药物敏感性
4. Erectile Dysfunction Drugs and Protein Expression of Glutathione S-transferase and Glutathione Peroxidase in the Liver of Male Rats [C] . SALAH A. SHEWEITA, BASANT SALAMA, MOSTAFA HASSAN MOSTAFA International Conference on Energy Systems, Environment, Entrepreneurship and Innovation . 2015

机译：雄性大鼠肝脏谷胱甘肽S-转移酶和谷胱甘肽过氧化物酶的勃起功能障碍药物和蛋白质表达
5. Towards enhanced cancer chemotherapy: Studies on drug design, synergy, and drug target expression and resistance with the combretastatins and other chemotherapeutics. [D] . Wehbe, Hania. 2005

机译：致力于增强癌症的化学疗法：研究康美他汀和其他化学疗法的药物设计，协同作用以及药物靶标的表达和耐药性。
6. Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy [O] . Chongyuan Zhang, Zhenge Zhang, Shuirong Zhang, 2017

机译：驱虫药Pyrvinium靶向Wnt /β-Catenin可增强卵巢癌细胞对化疗的敏感性
7. Targeting of Wnt/β-Catenin by Anthelmintic Drug Pyrvinium Enhances Sensitivity of Ovarian Cancer Cells to Chemotherapy [O] . Chongyuan Zhang, Zhenge Zhang, Shuirong Zhang, 2017

机译：靶向WNT /β-catenin的靶向ZHELMINTIC药物吡尼鎓增强卵巢癌细胞对化疗的敏感性

MicroRNA-133b targets glutathione S-transferase π expression to increase ovarian cancer cell sensitivity to chemotherapy drugs

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