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Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres

机译：负载利福喷丁微球的骨样羟基磷灰石/聚氨基酸治疗金黄色葡萄球菌引起的慢性骨髓炎

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摘要

PurposeThe purpose of this study was to investigate the curative effect of bone-like hydroxyapatite/poly amino acid (BHA/PAA) as a carrier for poly(lactic-co-glycolic acid)-coated rifapentine microsphere (RPM) in the treatment of rabbit chronic osteomyelitis induced by Staphylococcus aureus.

机译：目的本研究的目的是研究骨样羟基磷灰石/聚氨基酸（BHA / PAA）作为聚乳酸-乙醇酸涂层利福喷丁微球（RPM）载体的治疗效果金黄色葡萄球菌引起的慢性骨髓炎。

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期刊名称 Drug Design Development and Therapy
作者
Ling Yan; Dian-Ming Jiang; Zhi-Dong Cao; Jun Wu; Xin Wang; Zheng-Long Wang; Ya-Jun Li; Yong-Fen Yi;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 3665–3676
总页数 12
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
osteomyelitis antibiotics-loaded bone materials bone defect antimicrobial osteoconduction;

机译：骨髓炎;加载抗生素的骨材料;骨缺损;抗菌;骨传导;

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专利

1. Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with?rifapentine microspheres [J] . Ling Yan, Dian-Ming Jiang, Zhi-Dong Cao, Drug Design, Development and Therapy . 2015,第5期

机译：负载有利福喷丁微球的骨样羟基磷灰石/聚氨基酸治疗金黄色葡萄球菌引起的慢性骨髓炎
2. Release characteristics of bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres in vivo [J] . Liu Yuwu, Zhu Jiming, Jiang Dianming Molecular medicine reports . 2017,第2aPta1期

机译：骨样羟基磷灰石/聚氨基酸的释放特性加载二兆内微球的体内
3. Effect of bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres on bone and joint tuberculosis in vitro [J] . Liu Yuwu, Jiang Dianming Cell biology international. . 2017,第4期

机译：骨样羟基磷灰石/聚氨基酸的影响在体外骨和关节结核中的二淀粉微球加载
4. Enzyme loaded poly(lactic-co-glycolic acid) nanoparticles as anti-biofilm treatment strategy for chronic biofilm infections [C] . Chendong Han, Goodwine James S., Romero Nicholas, 2015 41st Annual Northeast Biomedical Engineering Conference . 2015

机译：负载酶的聚乳酸-乙醇酸纳米颗粒作为慢性生物膜感染的抗生物膜治疗策略
5. Development and characterization of methotrexate loaded poly(L-lactic acid) microspheres for the treatment of rheumatoid arthritis. [D] . Liang, Sanching Linda. 2006

机译：甲氨蝶呤负载聚（L-乳酸）微球的开发和表征，用于治疗类风湿关节炎。
6. In vitro and in vivo drug release and antibacterial properties of the novel vancomycin-loaded bone-like hydroxyapatite/poly amino acid scaffold [O] . Zhidong Cao, Dianming Jiang, Ling Yan, 2017

机译：新型负载万古霉素的骨样羟基磷灰石/聚氨基酸支架的体外和体内药物释放和抗菌性能
7. Biosafety of the Novel Vancomycin-loaded Bone-like Hydroxyapatite/Poly-amino Acid Bony Scaffold [O] . Zhi-Dong Cao, Dian-Ming Jiang, Ling Yan, 2016

机译：新型万古霉素负载骨样羟基磷灰石/聚氨基酸骨性支架的生物安全性
8. Osteomyelitis Treatment with Nanometer-Sized Hydroxyapatite Particles as a Delivery Vehicle for a Ciprofloxacin- Bisphosphonate Conjugate; New Fluoroquinolone-Bisphosphonate Derivatives Show Similar Binding Affinity to Hydroxyapatite and Improved Antibacterial Activity Against Drug-Resistant Pathogens [R] . McPherson, I. J., Runner, R. R., Shapiro, B. A., 2008

机译：用纳米羟基磷灰石颗粒作为环丙沙星 - 二膦酸盐缀合物的递送载体治疗骨髓炎;新的氟喹诺酮 - 二膦酸盐衍生物显示出与羟基磷灰石类似的结合亲和力和改善的抗药物病原体的抗菌活性

Treatment of Staphylococcus aureus-induced chronic osteomyelitis with bone-like hydroxyapatite/poly amino acid loaded with rifapentine microspheres

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