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Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx

机译：肿瘤特异性调幅射频电磁场通过靶向Cav3.2 T型电压门控钙通道和Ca2 +内流诱导肝癌的分化

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摘要

BackgroundAdministration of amplitude modulated 27·12 MHz radiofrequency electromagnetic fields (AM RF EMF) by means of a spoon-shaped applicator placed on the patient's tongue is a newly approved treatment for advanced hepatocellular carcinoma (HCC). The mechanism of action of tumour-specific AM RF EMF is largely unknown.

机译：背景技术通过放置在患者舌头上的汤匙形施药器对调幅的27·12 radioMHz射频电磁场（AM RF EMF）进行管理是新批准的晚期肝细胞癌（HCC）治疗方法。肿瘤特异性AM RF EMF的作用机理在很大程度上尚不清楚。

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期刊名称 EBioMedicine
作者
Hugo Jimenez; Minghui Wang; Jacquelyn W. Zimmerman; Michael J. Pennison; Sambad Sharma; Trevor Surratt; Zhi-Xiang Xu; Ivan Brezovich; Devin Absher; Richard M. Myers; Barry DeYoung; David L. Caudell; Dongquan Chen; Hui-Wen Lo; Hui-Kuan Lin; Dwayne W. Godwin; Michael Olivier; Anand Ghanekar; Kui Chen; Lance D. Miller; Yijian Gong; Myles Capstick; Ralph B. DAgostino Jr; Reginald Munden; Philippe Merle; Alexandre Barbault; Arthur W. Blackstock; Herbert L. Bonkovsky; Guang-Yu Yang; Guangxu Jin; Liang Liu; Wei Zhang; Kounosuke Watabe; Carl F. Blackman; Boris C. Pasche;
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年(卷),期 2019(44),-1
年度 2019
页码 209–224
总页数 16
原文格式 PDF
正文语种
中图分类
关键词
Advanced hepatocellular carcinoma T-type voltage gated calcium channels Calcium influx Cav 3·2 CACNA1H Amplitude-modulated Radiofrequency Electromagnetic fields AM RF EMF;

机译：晚期肝细胞癌;T型电压门控钙通道;钙内流;Cav 3·2;CACNA1H;调幅;射频;电磁场;AM RF EMF;

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专利

1. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2?T-type voltage-gated calcium channels and Ca2+ influx [J] . Hugo Jimenez, Minghui Wang, Jacquelyn W. Zimmerman, EBioMedicine . 2019,第7期

机译：肿瘤特异性调幅射频电磁场通过靶向Cav3.2？T型电压门控钙通道和Ca2 +流入诱导肝细胞癌的分化
2. CaV3.2 T-type Ca2+ channels mediate the augmented calcium influx in carotid body glomus cells by chronic intermittent hypoxia [J] . Makarenko Vladislav V., Ahmmed Gias U., Peng Ying-Jie, Journal of Neurophysiology . 2016,第1期

机译：CaV3.2 T型Ca2 +通道通过慢性间歇性缺氧介导颈动脉体球细胞的钙内流增加
3. Tarantula toxin ProTx-I differentiates between human T-type voltage-gated Ca2+ channels Cav3.1 and Cav3.2 [J] . OhkuboT., YamazakiJ., KitamuraK. Journal of pharmacological sciences. . 2010,第4期

机译：狼蛛毒素ProTx-I区分人T型电压门控Ca2 +通道Cav3.1和Cav3.2
4. The Effect of Low Levels of Amplitude-Modulated Electromagnetic Fields on Hepatocellular Carcinoma (HCC) Cells [C] . Jacquelyn Zimmerman, Frederico P. Costa, Ivan Brezovich, Meeting of the Bioelectromagnetics Society . 2010

机译：低水平幅度调制电磁场对肝细胞癌（HCC）细胞的影响
5. In vivo loss of estrogen increases Ca2+ influx via voltage-gated calcium channels in mesenteric arterial smooth muscle cells. [D] . Fernando, Charmain Angela. 2013

机译：体内雌激素的损失通过电压门控的钙离子通道增加肠系膜动脉平滑肌细胞中的Ca2 +流入。
6. Dorsal root ganglion neurons become hyperexcitable and increase expression of voltage-gated T-type calcium channels (Cav3.2) in paclitaxel-induced peripheral neuropathy [O] . Yan Li, Claudio Esteves Tatsui, Laurence D. Rhines, -1

机译：紫杉醇诱发的周围神经病变中背根神经节神经元变得过度兴奋并增加电压门控T型钙通道（Cav3.2）的表达
7. Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx [O] . Hugo Jimenez, Minghui Wang, Jacquelyn W. Zimmerman, 2019

机译：肿瘤特异性幅度调节的射频电磁场通过靶向CAV3.2 T型电压门控通道和CA2 +流入的肝细胞癌分化诱导肝细胞癌分化

Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx

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Tumour-specific amplitude-modulated radiofrequency electromagnetic fields induce differentiation of hepatocellular carcinoma via targeting Cav3.2 T-type voltage-gated calcium channels and Ca2+ influx