Large contractors in Africa: conundrums with malaria chemoprophylaxis

摘要

BackgroundDespite high levels of naturally-acquired immunity (NAI) within local communities in malaria high transmission settings in Africa, such people often experience clinical disease during peak transmission months due to high parasite challenge. Major recruiters of unskilled labour in high-transmission malaria settings in Africa generally withhold chemoprophylactic medication from this large component of their labour force, which if administered during peak “malaria season” could reduce incidence of clinical malaria without unduly affecting NAI.