Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice and Molecular Mechanisms in Vitro

摘要

Background: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT during in utero development at relatively high doses, but little was known about the effects of DBT exposure at environmentally relevant doses on endpoints such as obesity and metabolic disease.