Background Arsenic is a carcinogen to which 35 million people in Bangladesh are chronically exposed. The enzymatic transfer of methyl groups to inorganic As (iAs) generates monomethylarsonic (MMA) and dimethylarsinic acids (DMA) and facilitates urinary As (uAs) elimination. This process is dependent on one-carbon metabolism, a pathway in which folate and cobalamin have essential roles in the recruitment and transfer of methyl groups. Although DMAV is the least toxic metabolite, increasing evidence suggests that MMAIII may be the most cytotoxic and genotoxic As intermediary metabolite.
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机译：背景砷是一种致癌物质，孟加拉国有3500万人长期暴露在其中。甲基向无机As（iAs）的酶促转移生成单甲基ar（MMA）和二甲基ar酸（DMA），并促进尿As（uAs）的消除。这个过程取决于单碳代谢，叶酸和钴胺素在甲基的募集和转移中起着至关重要的作用。尽管DMA V 是毒性最低的代谢产物，但越来越多的证据表明MMA III 作为中间代谢产物可能是最具细胞毒性和遗传毒性的。
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