Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies

摘要

Background Despite experimental evidence, most epidemiologic studies to date have not supported an association between exposure to persistent organic pollutants (POP) and breast cancer incidence in humans. This may be attributable to difficulties in estimating blood/tissue POP concentration at critical time periods of carcinogenesis.