Association between NAT2 CYP1A1 and CYP1A2 genotypes heterocyclic aromatic amines and prostate cancer risk: a case control study in Japan

摘要

BackgroundHeterocyclic aromatic amines (HAAs) may confer prostate cancer risk; however, the evidence is inconclusive and the activity of HAA-metabolizing enzymes is modulated by gene variants. The purpose of our study was to determine whether there was evidence of an association between HAA intake, polymorphisms in NAT2, CYP1A1, and CYP1A2 and prostate cancer risk in Japanese men.