Proteomic analysis reveals differential protein expression in variants of papillary thyroid carcinoma

摘要

class="kwd-title">Keywords: Papillary thyroid carcinoma, IQGAP, Proteomics, Mass spectrometry class="head no_bottom_margin" id="abs0015title">AbstractIntroductionFine Needle Aspiration Biopsy (FNAB) allows the cytological differentiation of benign and malignant thyroid nodules. However, the method itself is not adequate in determining some cases. For example, the diagnosis of Follicular Variant Papillary Thyroid Carcinoma (FV-PTC) can be challenging. In the current study we investigate the protein profiles of FV-PTC and classical variant PTC (CV-PTC) with no lymph node metastasis and compare it with benign thyroid tissue.