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Promoter Sequences Prediction Using Relational Association Rule Mining

机译:关系关联规则挖掘的启动子序列预测

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摘要

In this paper we are approaching, from a computational perspective, the problem of promoter sequences prediction, an important problem within the field of bioinformatics. As the conditions for a DNA sequence to function as a promoter are not known, machine learning based classification models are still developed to approach the problem of promoter identification in the DNA. We are proposing a classification model based on relational association rules mining. Relational association rules are a particular type of association rules and describe numerical orderings between attributes that commonly occur over a data set. Our classifier is based on the discovery of relational association rules for predicting if a DNA sequence contains or not a promoter region. An experimental evaluation of the proposed model and comparison with similar existing approaches is provided. The obtained results show that our classifier overperforms the existing techniques for identifying promoter sequences, confirming the potential of our proposal.
机译:在本文中,我们从计算的角度探讨了启动子序列预测的问题,这是生物信息学领域的一个重要问题。由于DNA序列起启动子的条件尚不清楚,因此仍在开发基于机器学习的分类模型来解决DNA中启动子识别的问题。我们提出了一种基于关系关联规则挖掘的分类模型。关系关联规则是关联规则的一种特殊类型,它描述了通常在数据集中出现的属性之间的数字顺序。我们的分类器基于发现相关关联规则的知识,这些规则可预测DNA序列是否包含启动子区域。提供了对所提出模型的实验评估,并与类似的现有方法进行了比较。获得的结果表明,我们的分类器优于现有的鉴定启动子序列的技术,证实了我们的建议的潜力。

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