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Add-On Effect of Chinese Herbal Medicine Bath to Phototherapy for Psoriasis Vulgaris: A Systematic Review

机译:中草药浴对寻常型银屑病光疗的附加作用:系统评价

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摘要

Psoriasis vulgaris is the most common form of psoriasis. Phototherapy has been proven effective for psoriasis, but side effects have become a concern. Chinese herbal medicine (CHM) bath combined with phototherapy has been used in clinical settings, but the additional benefit requires evaluation. This review aims to evaluate the additional benefit and safety of adding CHM bath to phototherapy for psoriasis vulgaris. Cochrane library, PubMed, Embase, CNKI, and CQVIP were searched from their inceptions to 6 August 2012. Randomized controlled trials (RCTs) comparing CHM bath plus phototherapy to phototherapy alone for psoriasis vulgaris were included. Data was analyzed using Review Manager 5.1.0. Thirteen RCTs were included in the review, and eight were included in the meta-analysis. Meta-analysis showed higher efficacy of CHM bath plus phototherapy when compared with phototherapy alone in terms of PASI 60 (RR 1.25; 95% CI: 1.18–1.32). Mild adverse events were reported in ten studies, but these could be alleviated by reducing UV dosage or applying emollient. In conclusion, CHM bath appears to be a beneficial and safe adjunctive therapy to phototherapy for psoriasis vulgaris. However, these results should be interpreted with caution due to the low methodological quality of the included studies.
机译:寻常型牛皮癣是牛皮癣的最常见形式。光疗已被证明对牛皮癣有效,但副作用已成为一个问题。在临床环境中已使用中草药(CHM)浴与光疗相结合,但需要评估其附加益处。这篇综述旨在评估寻常型牛皮癣在光疗中添加CHM浴的额外益处和安全性。从Cochrane图书馆,PubMed,Embase,CNKI和CQVIP的数据库开始检索到2012年8月6日。其中包括比较寻常型银屑病CHM浴加光疗与仅光疗的随机对照试验(RCT)。使用Review Manager 5.1.0分析数据。该评价纳入了13篇RCT,荟萃分析中包括了8篇。荟萃分析显示,与单独使用光疗相比,PAM 60可使CHM浴加光疗的疗效更高(RR 1.25; 95%CI:1.18–1.32)。十项研究报告了轻度不良事件,但可以通过减少紫外线剂量或使用润肤剂缓解这些不良事件。总之,对于寻常型牛皮癣,CHM浴似乎是光疗的有益且安全的辅助疗法。但是,由于纳入研究的方法学质量低,因此应谨慎解释这些结果。

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