A 2-year-old girl experienced cardiac arrest after cold water drowning. Magnetic resonance imaging (MRI) showed deep gray matter injury on day 4 and cerebral atrophy with gray and white matter loss on day 32. Patient had no speech, gait, or responsiveness to commands on day 48 at hospital discharge. She received normobaric 100% oxygen treatment (2 L/minute for 45 minutes by nasal cannula, twice/day) since day 56 and then hyperbaric oxygen treatment (HBOT) at 1.3 atmosphere absolute (131.7 kPa) air/45 minutes, 5 days/week for 40 sessions since day 79; visually apparent and/or physical examination-documented neurological improvement occurred upon initiating each therapy. After HBOT, the patient had normal speech and cognition, assisted gait, residual fine motor and temperament deficits. MRI at 5 months after injury and 27 days after HBOT showed near-normalization of ventricles and reversal of atrophy. Subacute normobaric oxygen and HBOT were able to restore drowning-induced cortical gray matter and white matter loss, as documented by sequential MRI, and simultaneous neurological function, as documented by video and physical examinations.
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机译:一名2岁女孩在冷水淹没后经历了心脏骤停。磁共振成像(MRI)在第4天显示出深灰色物质损伤,在第32天出现脑萎缩,并失去了灰色和白色物质。在出院的第48天,患者没有言语,步态或对命令的反应。自第56天起,她接受了常压100%氧气处理(2 L /分钟,经鼻插管持续45分钟,每天两次,每天两次),然后在1.3大气压绝对压力(131.7 kPa)空气/ 45分钟,5天/下进行了高压氧治疗(HBOT)从第79天开始,每周进行40次训练;开始每种疗法后,视觉上和/或体检证明的神经功能都有改善。 HBOT后,患者的言语和认知正常,步态辅助,残余精细运动和气质缺陷。受伤后5个月和HBOT后27天的MRI显示心室接近正常,萎缩逆转。亚急性常压氧气和HBOT能够恢复溺水诱发的皮质灰质和白质流失,如顺序MRI所记录,同时具有神经功能,如视频和体格检查所记录。
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